Drug Uses

Wellbutrin SR (Anti Depressant) is a pharmaceutical prescription antidepressant, which acts directly on the brain and other nerve cells. It is also used to treat ADHD (Attention Deficit Disorder), bipolar depression, chronic fatigue syndrome, cocaine addiction, nicotine addiction, and lower back pain. Also, aids in quitting smoking (identical to Zyban). It is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents.

How Taken

Wellbutrin SR comes as a tablet to take it orally. It is usually taken one to three times a day and may be taken with or without food. Do not crush, chew, or divide Wellbutrin SR. Do not stop taking Wellbutrin SR without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want to decrease your dose gradually. This drug must be taken regularly for a few weeks before its full effect is felt.

Warnings/Precautions

Before taking Wellbutrin SR, tell your doctor if you have: history of seizures or head injury or brain tumor, heart disease, liver or kidney disease, eating disorder, diabetes, alcohol dependence, any allergies, the intent to quit smoking. Because of the possibility this drug will make you dizzy and affect coordination, do not drive or operate machinery until you get used to the drug's effects. Limit or avoid consumption of alcoholic beverages; alcohol can increase your risk of seizures. Chronic alcohol users who suddenly stop the intake of alcohol while taking Wellbutrin SR may increase the risk of having seizures. Suddenly stopping certain tranquilizers is not recommended because doing so may increase the risk of having seizures. If you are over 65 years old you may be more sensitive to the effects of this drug. Tell your doctor if you are pregnant or plan to become pregnant before taking this drug. This drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Missed Dose

Take any missed dose as soon as possible but not if it is within 4 hours of the next dose. If it is time for the next dose, skip the missed dose and resume your regular schedule. Do not "double-up" the dose.

Possible Side Effects

This medication is generally well tolerated. Dry mouth, headache, increased sweating, nausea/vomiting, constipation, anxiety, fatigue and blurred vision may occur. If these effects persist or worsen, notify your doctor. Report promptly: unusual weight loss or gain, palpitations, agitation, trouble sleeping. Unlikely but report promptly: tremor, dizziness, fainting, mood changes, slowed movements, difficulty urinating, decreased sex drive, and drowsiness. Very unlikely but report promptly: seizures, mental problems, fever, muscle aches, yellowing of the eyes or skin. In the unlikely event you have an allergic reaction to this drug, seek medical attention immediately. Symptoms may include trouble breathing, rash, itching, swelling, or severe dizziness. If you notice other effects not listed above, contact your doctor or pharmacist.

Storage

Store at controlled room temperature, 20° to 25°C (68° to 77°F). Dispense in a tight, light-resistant container.

Overdose

Seek emergency medical attention if an overdose is suspected. Symptoms of a Wellbutrin SR overdose include seizures, hallucinations, loss of consciousness, weakness, a fast heartbeat, and heart attack.

More Information

Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall. Too much of this medicine can increase the risk of a seizure. Limit the consumption of caffeine while taking Wellbutrin SR.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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We also recommend regular "drug checks" with your doctors. You may be able to switch to lower–cost generics, or to one of our Rx-pharmacy-drugs.com. Even if you have coverage, you may be able to save hundreds of dollars by switching to less expensive generics or by buying from Rx-pharmacy-drugs.com. Drug stores even in a single town or city can charge prices for the same drugs that vary by 50% or more. Shopping wisely for Wellbutrin can also save you money. This may mean buying drugs online or through mail order, checking prices at local pharmacies and discount stores, and getting a 90–day supply of any medicines you take on a regular basis.

Q: What happens when I submit my Wellbutrin order?
A: Your order is dispatched through our order system to a licensed physician who will review the information you have submitted and approve or decline your request of Wellbutrin. When your order is approved, the physician will then write your prescription and our ordering system will ensure that it is sent to the pharmacy where it will be filled and shipped.


How Anti-Depressants Create New Brain Cells
Science Daily — Antidepressants increase the presence of a growth factor in the brain, which then leads to a proliferation of new cells, according to a study by Yale School of Medicine researchers in this week’s Proceedings of the National Academy of Sciences.
The study describes for the first time the molecular mechanisms and the identity of the protein, vascular endothelial growth factor (VEGF), which underlie the actions of antidepressants on new cell growth and behavior.
“One in five Americans have depression, yet the neural mechanisms underlying depression and the actions of antidepressants remain unknown,” said Ronald Duman, senior author and professor of psychiatry at Yale. “These findings provide important, fundamental, and new information on the actions of these highly prescribed drugs. The data also has implications for understanding many stress related disorders.”
Duman and Jennifer Warner-Schmidt, a former graduate student at Yale now at the Rockefeller Institute, found in a rodent study that VEGF levels are increased by chronic administration of either of two major classes of antidepressant medications. Conversely, blocking the effects of VEGF prevents new cell birth in response to the medications.
Duman said recent studies demonstrated that stress decreases the expression of VEGF in the hippocampus, a region of the brain involved in the control of emotion, mood, learning, and memory, and this could contribute to the atrophy and loss of cells caused by stress and depression.
In prior groundbreaking research Duman found that antidepressants increase the expression of growth factors in the hippocampus and other regions of the brain. Duman also found that antidepressants increase the birth of new neurons in the hippocampus.
According to Duman, future studies could look at VEGF and related pathways for genetic mutations that might contribute to depression, or make a person more susceptible to depression. VEGF signaling also could provide targets for the development of novel, faster acting, and more effective therapeutic agents.

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